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KH-4-43

Catalog #: 8091 Datasheet / COA / SDS
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8091/5

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KH-4-43 | CAS No. 2813310-07-3 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective CUL4 inhibitor

Chemical Name: 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one

Purity: ≥98%

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Biological Activity

KH-4-43 is a selective CUL4 inhibitor (Kd = 83 nM). KH-4-43 inhibits the ubiquitination of CK1α by CRL4CRBN in vitro. Treatment of cells with KH-4-43 causes accumulation of the E3 CRL4 substrate CDT1. KH-4-43 suppresses the growth of human tumor xenografts in mice.

Technical Data

M.Wt:
422.74
Formula:
C19H10ClF3N2O4
Solubility:
Soluble to 20 mM in ethanol with gentle warming and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2813310-07-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Icahn School of Medicine at Mount Sinai.

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