KH 7

Tocris Bioscience | Catalog # 3834

Selective soluble adenylyl cyclase inhibitor
Tocris Bioscience

Key Product Details

Description

Selective soluble adenylyl cyclase inhibitor
View all Adenylyl Cyclase Inhibitors »

Product Description

KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Product Specifications for KH 7

Molecular Weight

419.30

Formula

C17H15BrN4O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

CAS Number

330676-02-3

PubChem ID

6843191

InChI Key

GEHVZUUHMWNMAY-UHFFFAOYSA-N

SMILES

OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.93 100

Preparing Stock Solutions for KH 7

The following data is based on the product molecular weight 419.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.85 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

Product Documents for KH 7

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KH 7

For research use only

Customer Reviews for KH 7 (1)

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  • a selective sAC inhibitor
    Name: Hyun Choi
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/31/2018
    pretreat KH7 at least 30 min before treatment
    Used KH7 to block soluble adenylyl cyclase which is sensitive to bicarbonate. Used at 20uM in rat brain slice.

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