KML 29

Key Product Details

Product Description

KML 29 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC₅₀ values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC₅₀ > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC₅₀ = 2.5 nM and >50 μM for 2-AG and AEA respectively).

Licensing Information

Sold under license from The Scripps Research Institute

Product Specifications for KML 29

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KML 29

The following data is based on the product molecular weight 549.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.82 mL	9.10 mL	18.20 mL
5 mM	0.36 mL	1.82 mL	3.64 mL
10 mM	0.18 mL	0.91 mL	1.82 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Chang Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 2012 PMID: 22542104
• Ueda Discrimination between two endocannabinoids. Chem.Biol. 2012 PMID: 22633404

Product Documents for KML 29