KN 93

Tocris Bioscience | Catalog # 1278

CaM kinase II inhibitor; also K+ channel blocker (KV)
Tocris Bioscience

Key Product Details

Description

CaM kinase II inhibitor; also K+ channel blocker (KV)
View all Calcium Binding Protein Modulator Inhibitors »

Product Description

KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.

Water soluble form and Negative Control also available.

Product Specifications for KN 93

Molecular Weight

501.04

Formula

C26H29ClN2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide

CAS Number

139298-40-1

PubChem ID

5312122

InChI Key

LLLQTDSSHZREGW-AATRIKPKSA-N

SMILES

O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.1 100 with gentle warming

Preparing Stock Solutions for KN 93

The following data is based on the product molecular weight 501.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.00 mL 9.98 mL 19.96 mL
5 mM 0.40 mL 2.00 mL 3.99 mL
10 mM 0.20 mL 1.00 mL 2.00 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 182 publications citing the usage of this product.

Product Documents for KN 93

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KN 93

For research use only

Customer Reviews for KN 93 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used KN 93?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • KN93 ameliorates HOCl-LDL-reduced ICa,L density in cardiomyocytes
    Name: Christopher Trummer
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/22/2018
    Guinea pig ventricular cardiomyocytes were treated with HOCl-LDL (250 µg/ml, 12-16 h)in the absence or presence of KN93 (5 µM) to follow L-type Ca2+ current (ICa,L) using patch clamp analysis. KN93 ameliorated HOCl-LDL-reduced ICa,L density.
    KN 93 1278

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All