KT 5823

Key Product Details

Product Description

KT 5823 is a selective inhibitor of protein kinase G (K_i values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC₅₀ of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Product Specifications for KT 5823

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KT 5823

The following data is based on the product molecular weight 495.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.04 mL	20.18 mL	40.36 mL
2.5 mM	0.81 mL	4.04 mL	8.07 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
25 mM	0.08 mL	0.40 mL	0.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 64 publications citing the usage of this product.

• Murthy and Makhlouf Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 1995 PMID: 7840145
• Smolenski Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 1998 PMID: 9721015
• Gadbois Multiple kinase arrest points in the G₁ phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1528872

Product Documents for KT 5823