KU 55933

Tocris Bioscience | Catalog # 3544

Potent and selective ATM kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective ATM kinase inhibitor
View all ATM and ATR Kinase Inhibitors »

Product Description

KU 55933 is a potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Product Specifications for KU 55933

Molecular Weight

395.49

Formula

C21H17NO3S2

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

CAS Number

587871-26-9

PubChem ID

5278396

InChI Key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

SMILES

O=C1C=C(C3=CC=CC4=C3SC5=C(C=CC=C5)S4)OC(N2CCOCC2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100
Ethanol 19.77 50

Preparing Stock Solutions for KU 55933

The following data is based on the product molecular weight 395.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 286 publications citing the usage of this product.

Product Documents for KU 55933

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KU 55933

For research use only

Customer Reviews for KU 55933 (2)

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  • ATM inhibitor
    Name: Isabelle Cristine da Costa
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: U2OS
    Verified Customer | Posted 09/23/2021
    I used this ATM inhibitor (ATMi - KU55933) to treat human osteosarcoma cells and then I blotted for pATM (S1981) and for pCHK2 (T68) to assess ATM inhibition. It works incredibly well!
    KU 55933 3544
  • Inhibition of ATM results in DNA damage
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hela
    Verified Customer | Posted 02/29/2020
    HeLa cells transfected with in vitro transcribed I-PpoI and treated or not with inhibitors for KU 55933 and NU 7441 (iDPK)
    KU 55933 3544

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