KW 3902

Tocris Bioscience | Catalog # 4167

Selective A1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective A1 antagonist

Alternative Names

Rolofylline
View all Adenosine A1 Receptor Antagonists »

Product Description

KW 3902 is a selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

Product Specifications for KW 3902

Molecular Weight

356.46

Formula

C20H28N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione

CAS Number

136199-02-5

PubChem ID

64627

InChI Key

PJBFVWGQFLYWCB-UHFFFAOYSA-N

SMILES

O=C1C2=C(NC(C34CC(CC4C5)CC5C3)=N2)N(CCC)C(N1CCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.82 50
Ethanol 8.91 25

Preparing Stock Solutions for KW 3902

The following data is based on the product molecular weight 356.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.61 mL 28.05 mL 56.11 mL
2.5 mM 1.12 mL 5.61 mL 11.22 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for KW 3902

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KW 3902

For research use only

Customer Reviews for KW 3902 (1)

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  • systemic administration of KW3902
    Name: Ariel Vitenzon
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/05/2018
    The drug dissolves well in saline + 0.3% tween 80 with 3X vortex (1min) and sonicate (5min).
    We injected this drug at 1 mg/Kg and 2 mg/Kg systemically (IP) into transgenic mice and monitored the effect on motor behavior. The drug efficiently induced motor symptoms in the transgenic mice at these concentrations.

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