L-161,982

Tocris Bioscience | Catalog # 2514

Selective EP4 receptor antagonist
Tocris Bioscience

Key Product Details

Description

Selective EP4 receptor antagonist
View all Prostanoid Receptor Antagonists »

Product Description

L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by Misoprostol (Cat. No. 2297) in formalin-injected mice.

Product Specifications for L-161,982

Molecular Weight

654.72

Formula

C32H29F3N4O4S2

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

CAS Number

147776-06-5

PubChem ID

9961192

InChI Key

MMDNKTXNUZFVKD-UHFFFAOYSA-N

SMILES

CCCCC1=NN(C(=O)N1CC1=CC=C(C=C1)C1=C(C=CC=C1)S(=O)(=O)NC(=O)C1=C(C)C=CS1)C1=C(C=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 65.47 100

Preparing Stock Solutions for L-161,982

The following data is based on the product molecular weight 654.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.64 mL 15.27 mL
5 mM 0.31 mL 1.53 mL 3.05 mL
10 mM 0.15 mL 0.76 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for L-161,982

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-161,982

For research use only

Customer Reviews for L-161,982 (1)

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  • L-161,982
    Name: Melanie Ikeh
    Verified Customer | Posted 05/31/2017
    in vivo survival assay

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