L-655,708

Key Product Details

Product Description

L-655,708 is a potent, selective inverse agonist for the benzodiazepine site of GABA_A receptors containing the α5 subunit (K_i = 0.45 nM). Displays 50-100-fold selectivity over GABA_A receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Product Specifications for L-655,708

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-655,708

The following data is based on the product molecular weight 341.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.72 mL	58.59 mL	117.17 mL
1.25 mM	2.34 mL	11.72 mL	23.43 mL
2.5 mM	1.17 mL	5.86 mL	11.72 mL
12.5 mM	0.23 mL	1.17 mL	2.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 43 publications citing the usage of this product.

• Quirk [³H]L-655,708, a novel ligand selective for the benzodiazepine site of GABA_A receptors which contain the α5 subunit. Neuropharmacology 1996 PMID: 9014149
• Sur Rat and human hippocampal α5 subunit-containing γ-aminobutyric acid_A receptors have α5α3γ2 pharmacological characteristics. Mol.Pharmacol. 1998 PMID: 9804628
• Atack L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABA_A receptors. Neuropharmacology 2006 PMID: 17046030

Product Documents for L-655,708