L-701,324

Key Product Details

Product Description

L-701,324 is a an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-701,324

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-701,324

The following data is based on the product molecular weight 363.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.74 mL	27.49 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Obrenovitch and Zilkha Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex. Br.J.Pharmacol. 1996 PMID: 8851513
• Bristow Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 1996 PMID: 8930150
• Kulagowski 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 1994 PMID: 8182696
• Bristow The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 1996 PMID: 8627534

Product Documents for L-701,324