L-732,138

Key Product Details

Product Description

L-732,138 is a potent and highly selective competitive tachykinin NK₁ receptor antagonist (IC₅₀ = 2.3 nM).

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-732,138

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-732,138

The following data is based on the product molecular weight 472.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.17 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• MacLeod Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK₁ receptor. J.Med.Chem. 1994 PMID: 7513763
• Kuo Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 1998 PMID: 9831906
• MacLeod N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 1993 PMID: 8393115
• Cascieri Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 1994 PMID: 7509807

Product Documents for L-732,138