L-838,417

Tocris Bioscience | Catalog # 3250

GABAA partial agonist; displays subtype selectivity
Tocris Bioscience

Key Product Details

Description

GABAA partial agonist; displays subtype selectivity
View all GABA-A Receptor Agonists »

Product Description

L-838,417 is a subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Product Specifications for L-838,417

Molecular Weight

399.40

Formula

C19H19F2N7O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

CAS Number

286456-42-6

PubChem ID

9908880

InChI Key

BQDUNOMMYOKHEP-UHFFFAOYSA-N

SMILES

FC(C=CC(F)=C3)=C3C1=NN=C2N1N=C(OCC4=NC=NN4C)C(C(C)(C)C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.97 50

Preparing Stock Solutions for L-838,417

The following data is based on the product molecular weight 399.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.01 mL 25.04 mL 50.08 mL
2.5 mM 1.00 mL 5.01 mL 10.02 mL
5 mM 0.50 mL 2.50 mL 5.01 mL
25 mM 0.10 mL 0.50 mL 1.00 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for L-838,417

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-838,417

For research use only

Related Research Areas

GABA Receptors

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