L-AP4

Key Product Details

Product Description

L-AP4 is a selective group III metabotropic glutamate receptor agonist that acts at mGlu4, mGlu8, mGlu6 and mGlu7 receptors (EC₅₀ values = 0.1-0.13 μM, 0.29 μM, 1.0-2.4 μM and 249-337 μM, respectively). L-AP4 is a synaptic depressant and inhibits excitatory post-synaptic currents. L-AP4 is also an agonist at the quisqualate-sensitized AP6 site in hippocampus.

DL Mixture also available.

Product Specifications for L-AP4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-AP4

The following data is based on the product molecular weight 183.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 372 publications citing the usage of this product.

• Selvam Increased potency and selectivity for group III metabotropic glutamate receptor agonists binding at dual sites. J.Med.Chem. 2018 PMID: 29397723
• Tones The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. NeuroReport 1995 PMID: 8742431
• Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
• Nakanishi Molecular diversity of glutamate receptors and implications for brain functions. Science 1992 PMID: 1329206
• Bushell Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology 1995 PMID: 7617150

Product Documents for L-AP4