L-DON

Key Product Details

Product Description

L-DON is a glutaminase inhibitor (K_i = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.

Product Specifications for L-DON

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-DON

The following data is based on the product molecular weight 171.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	11.69 mL	58.43 mL	116.86 mL
2.5 mM	2.34 mL	11.69 mL	23.37 mL
5 mM	1.17 mL	5.84 mL	11.69 mL
25 mM	0.23 mL	1.17 mL	2.34 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ovejera Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 1979 PMID: 572261
• Lemberg We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine. Mol.Cancer Ther. 2018 PMID: 30181331
• Thomas Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors. Biochem.Biophys.Res.Commun. 2013 PMID: 23850693

Product Documents for L-DON