Latrunculin A

Tocris Bioscience | Catalog # 3973

Inhibitor of actin assembly and polymerization
Tocris Bioscience

Key Product Details

Description

Inhibitor of actin assembly and polymerization
View all Actin-related Products »

Product Description

Latrunculin A (LAT-A) is a marine toxin that binds ATP-actin (Kd = 0.1 µM), G-actin (Kd = 0.19 µM), ADP-Pi-actin (Kd = 0.4 µM) and ADP-actin (Kd = 4.7 µM) monomers in cells. By binding and sequestering actin monomers and preventing F-actin filament formation, LAT-A inhibits actin polymerization without significant direct effects on microtubules or other cytoskeletal components.

Latrunculin A can be used to transiently disrupt the actin cytoskeleton to investigate actin-dependent cellular functions including motility, shape maintenance, intracellular trafficking, and mechanotransduction. Latrunculin A displays anti-invasive activity against human prostate cancer cells and suppresses hypoxia-induced HIF-1 activation in breast tumour cells in vitro. Latrunculin A is also a potent inhibitor of phagocytosis by macrophages.

In vivo, it has been used in various model organisms to study cytoskeletal dynamics affecting processes such as cancer cell migration and morphogenesis. LAT-A has strong antitumor effect in mice models infected with adenocarcinoma or carcinoma.

Product Specifications for Latrunculin A

Molecular Weight

421.55

Formula

C22H31NO5S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

CAS Number

76343-93-6

PubChem ID

445420

InChI Key

DDVBPZROPPMBLW-IZGXTMSKSA-N

SMILES

C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 116 publications citing the usage of this product.

Product Documents for Latrunculin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Latrunculin A

For research use only

Customer Reviews for Latrunculin A

There are currently no reviews for this product. Be the first to review Latrunculin A and earn rewards!

Have you used Latrunculin A?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card