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LDN 209929 dihydrochloride

Catalog #: 4828 Datasheet / COA / SDS

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4828 has been discontinued.
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LDN 209929 dihydrochloride | CAS No. 1784281-97-5 | Haspin Inhibitors
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Description: Potent and selective haspin inhibitor

Chemical Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride

Purity: ≥98%

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Biological Activity

LDN 209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.

Technical Data

M.Wt:
405.77
Formula:
C17H17ClN2OS.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1784281-97-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.
    Cuny et al.
    Bioorg.Med.Chem.Lett., 2010;20:3491

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