LDN 212320

Tocris Bioscience | Catalog # 5082

Increases EAAT2 expression; neuroprotective
Tocris Bioscience
Discontinued Product
5082 has been discontinued. View all Glutamate (EAAT) Transporter Compounds products.

Key Product Details

Description

Increases EAAT2 expression; neuroprotective
View all Glutamate (EAAT) Transporter Compounds »

Product Description

LDN 212320 is a increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Product Specifications for LDN 212320

Molecular Weight

293.39

Formula

C17H15N3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

CAS Number

894002-50-7

PubChem ID

7207425

InChI Key

DUUQLWDHNYFUPP-UHFFFAOYSA-N

SMILES

CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
Ethanol 5.87 20

Preparing Stock Solutions for LDN 212320

The following data is based on the product molecular weight 293.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.70 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for LDN 212320

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LDN 212320

For research use only

Customer Reviews for LDN 212320 (1)

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  • Using LDN 212320 to increase GLT-1
    Name: Crystal Wilkie
    Species: Mouse
    Verified Customer | Posted 01/12/2018
    It's hard to dissolve so we dissolved it in 100ul of DMSO first before adding the vehicle.
    We used it to increase GLT-1 in mice brains. So far it has significantly increased GLT-1 after one injection.
    LDN 212320 5082

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