Levcromakalim

Tocris Bioscience | Catalog # 1378

Kir6 (KATP) channel opener; active enantiomer of Cromakalim
Tocris Bioscience

Key Product Details

Description

Kir6 (KATP) channel opener; active enantiomer of Cromakalim

Alternative Names

BRL 38227
View all Inward Rectifier Potassium Channel Activators »

Product Description

Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Product Specifications for Levcromakalim

Molecular Weight

286.33

Formula

C16H18N2O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

CAS Number

94535-50-9

PubChem ID

93504

InChI Key

TVZCRIROJQEVOT-CABCVRRESA-N

SMILES

O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.86 10

Preparing Stock Solutions for Levcromakalim

The following data is based on the product molecular weight 286.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.92 mL 174.62 mL 349.25 mL
0.5 mM 6.98 mL 34.92 mL 69.85 mL
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.70 mL 3.49 mL 6.98 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for Levcromakalim

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Levcromakalim

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Levcromakalim (1)

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  • Levcromakalim was used on BK channel opening properties compared to cromakalim
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/28/2018
    Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.
    Levcromakalim 1378

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