LL-K9-3

Tocris Bioscience | Catalog # 7813

Selective HyT-based degrader of the CDK9-cyclin T1 complex
Tocris Bioscience

Key Product Details

Description

Selective HyT-based degrader of the CDK9-cyclin T1 complex
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Product Description

LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC50 values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.

Product Specifications for LL-K9-3

Molecular Weight

683.94

Formula

C31H49N5O6S3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide

CAS Number

2809353-52-2

PubChem ID

164946948

InChI Key

NPRIWHDFWDSJRZ-YFNKSVMNSA-N

SMILES

O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 68.39 100
Ethanol 3.42 5

Preparing Stock Solutions for LL-K9-3

The following data is based on the product molecular weight 683.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.31 mL 14.62 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for LL-K9-3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LL-K9-3

For research use only

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