Chemical Name: 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
Biological ActivityLM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.
Yang T, Massa SM, Tran KC et al.
Citations for LM22B 10
The citations listed below are publications that use Tocris products. Selected citations for LM22B 10 include:
2 Citations: Showing 1 - 2
Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death.
Authors: Julia Et al.
Cell Death Dis 2022;13:887
Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.
Authors: Tigaret Et al.
Mol Psychiatry 2021;26:1748
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