LNT 1

Key Product Details

Product Description

LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC₅₀ = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.

Product Specifications for LNT 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LNT 1

The following data is based on the product molecular weight 332.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.02 mL	30.09 mL	60.18 mL
2.5 mM	1.20 mL	6.02 mL	12.04 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Ward Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 2017 PMID: 28628639
• Exell Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 2016 PMID: 27526030

Product Documents for LNT 1