Lonidamine

Key Product Details

Product Description

Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl^- channels in vitro.

Product Specifications for Lonidamine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lonidamine

The following data is based on the product molecular weight 321.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.11 mL	15.57 mL	31.14 mL
5 mM	0.62 mL	3.11 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.11 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Teiche Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 1994 PMID: 7833093
• Gong Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 2002 PMID: 12411425
• Lobl Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 1981 PMID: 6793318
• De Martino Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 1984 PMID: 6717891

Product Documents for Lonidamine