Loperamide hydrochloride

Tocris Bioscience | Catalog # 0840

Peripherally acting μ agonist; Ca2+ channel blocker
Tocris Bioscience
Discontinued Product
0840 has been discontinued. View all mu Opioid Receptor Agonists products.

Key Product Details

Description

Peripherally acting μ agonist; Ca2+ channel blocker
View all mu Opioid Receptor Agonists »

Product Description

Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro.

Product Specifications for Loperamide hydrochloride

Molecular Weight

513.51

Formula

C29H33ClN2O2.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride

CAS Number

34552-83-5

PubChem ID

71420

InChI Key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

SMILES

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.27 20
Ethanol 10.27 20

Preparing Stock Solutions for Loperamide hydrochloride

The following data is based on the product molecular weight 513.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.74 mL 48.68 mL 97.37 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
2 mM 0.97 mL 4.87 mL 9.74 mL
10 mM 0.19 mL 0.97 mL 1.95 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Loperamide hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Loperamide hydrochloride

For research use only

Citations for Loperamide hydrochloride

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