LP 922056

Key Product Details

Product Description

LP 922056 is a notum pectinacetylesterase inhibitor. LP 922056 activates wnt signaling in vitro (EC₅₀ values are 21 nM in human and 55 nM in mouse cell-based assay). It increases cortical bone thickness in mouse model of bone growth. LP 922056 also inhibits growth of Apc-mutant cell lines and proliferation of intestinal adenomas in vivo.

Product Specifications for LP 922056

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LP 922056

The following data is based on the product molecular weight 300.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.62 mL	33.25 mL
5 mM	0.66 mL	3.32 mL	6.65 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Brommage NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 PMID: 30622831
• Flanagan NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 2021 PMID: 34079124
• Tarver Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 2016 PMID: 26897593

Product Documents for LP 922056