LP 922761

Tocris Bioscience | Catalog # 6229

Potent AAK1 inhibitor; peripherally restricted
Tocris Bioscience
Discontinued Product
6229 has been discontinued. View all Other Kinase Inhibitors products.

Key Product Details

Description

Potent AAK1 inhibitor; peripherally restricted
View all Other Kinase Inhibitors »

Product Description

LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Product Specifications for LP 922761

Molecular Weight

410.47

Formula

C21H26N6O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate

CAS Number

1454808-95-7

PubChem ID

86696405

InChI Key

YNQNYIHMAZLJAV-UHFFFAOYSA-N

SMILES

CN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.52 50

Preparing Stock Solutions for LP 922761

The following data is based on the product molecular weight 410.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.87 mL 24.36 mL 48.72 mL
2.5 mM 0.97 mL 4.87 mL 9.74 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
25 mM 0.10 mL 0.49 mL 0.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LP 922761

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LP 922761

For research use only

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