LTGO-33

Key Product Details

Product Description

LTGO-33 is a potent and selective state-independent inhibitor of Na_V1.8 sodium channels (IC₅₀ = 13 nM for the closed state; IC₅₀ = 24 nM for the inactive state). It displays 600-fold selectivity over other sodium channels such as Na_V1.1-1.7 and Na_V1.9. By binding to Na_V1.8 channels, LTGO-33 inhibits action potential initiation and transmission of pain signals in human DRG neurons. Unlike other Na_V1.8 inhibitors that preferentially interact with an inactivated state via the pore region, LTGO-33 is state-independent with similar potencies against closed and inactivated channels.

Licensing Information

Sold with kind permission of Latigo Biotherapeutics

Product Specifications for LTGO-33

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LTGO-33

The following data is based on the product molecular weight 467.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.70 mL	21.39 mL
5 mM	0.43 mL	2.14 mL	4.28 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gilchrist Pharmacologic characterization of LTGO-33, a selective small molecule inhibitor of the voltage-gated sodium channel NaV1.8 with a unique mechanism of action. Mol.Pharmacol 2024 PMID: 38195157

Product Documents for LTGO-33