Lu AA 47070

Key Product Details

Product Description

Prodrug of a potent and selective adenosine A_2A receptor antagonist (K_i values are 5.9, 260, 410 and <10,000 nM for A_2A, A_2B, A₁ and A₃ receptors respectively. Reverses parkinsonian motor impairment and motivational effects produced by dopamine D₂ receptor blockade in rats. Orally bioavailable.

Product Specifications for Lu AA 47070

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lu AA 47070

The following data is based on the product molecular weight 463.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Collins The novel adenosine A_2A antagonist Lu AA47070 reverses the motor and motivational effects produced by DA D₂ receptor blockade. Pharmacol.Biochem.Behav. 2012 PMID: 22037410
• Sams Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA_2A receptor antagonist. J.Med.Chem. 2011 PMID: 21210664

Product Documents for Lu AA 47070