LUF 5834

Key Product Details

Product Description

LUF 5834 is a potent A_2A and A_2B adenosine receptor partial agonist (K_i = 2.6 nM and EC₅₀ = 12 nM respectively). Also exhibits selectivity for A₁ over A₃ (K_i values are 2.6 and 538 nM respectively).

Product Specifications for LUF 5834

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LUF 5834

The following data is based on the product molecular weight 348.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Lane A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A_2a receptor Mol.Pharmacol. 2012 PMID: 22188926
• Beukers New, non-adenosine, high potency agonists for the human adenosine A_2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 2004 PMID: 15239649

Product Documents for LUF 5834