LY 2119620

Key Product Details

Product Description

LY 2119620 is a positive allosteric modulator of M₂ and M₄ muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M₂ and M₄ in presence of ACh, respectively. Binds in extracellular site.

Product Specifications for LY 2119620

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 2119620

The following data is based on the product molecular weight 437.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.83 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kruse Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013 PMID: 24256733
• Croy Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M₂ and M₄ receptors. Mol.Pharmacol. 2014 PMID: 24807965

Product Documents for LY 2119620