LY 354740

Key Product Details

Product Description

LY 354740 is a highly selective and potent agonist of group II mGlu receptors (EC₅₀ values are 5.1 and 24.3 nM at mGlu₂ and mGlu₃ receptors respectively and > 100000 nM at mGlu₄, mGlu₇, mGlu_1a and mGlu_5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.

Product Specifications for LY 354740

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 354740

The following data is based on the product molecular weight 185.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.40 mL	27.00 mL	54.00 mL
5 mM	1.08 mL	5.40 mL	10.80 mL
10 mM	0.54 mL	2.70 mL	5.40 mL
50 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 42 publications citing the usage of this product.

• Helton Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 1998 PMID: 9454811
• Klodzinska Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology 1999 PMID: 10608278
• Schoepp LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors. Neuropharmacology 1997 PMID: 9144636

Product Documents for LY 354740