LY 379268

Key Product Details

Product Description

LY 379268 is a highly selective group II mGlu receptor agonist (EC₅₀ values are 2.69 and 4.48 nM for hmGlu₂ and hmGlu₃ respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. LY379268 disodium salt also available.

Licensing Information

Sold under license from Eli Lilly and Company

Product Specifications for LY 379268

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 379268

The following data is based on the product molecular weight 187.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.34 mL	26.72 mL	53.43 mL
5 mM	1.07 mL	5.34 mL	10.69 mL
10 mM	0.53 mL	2.67 mL	5.34 mL
50 mM	0.11 mL	0.53 mL	1.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 129 publications citing the usage of this product.

• Bond Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 2000 PMID: 10945827
• Collado (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 2002 PMID: 12166935
• Bond LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 1999 PMID: 10515191

Product Documents for LY 379268