LY 78335

Key Product Details

Product Description

LY 78335 is a high affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (K_i = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

Product Specifications for LY 78335

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 78335

The following data is based on the product molecular weight 226.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.41 mL	22.07 mL	44.14 mL
5 mM	0.88 mL	4.41 mL	8.83 mL
10 mM	0.44 mL	2.21 mL	4.41 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Terry Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 1982 PMID: 7054231
• Grunewald Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 1988 PMID: 3351861
• Fuller Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 1973 PMID: 4683104

Product Documents for LY 78335