M8 B hydrochloride

Key Product Details

Product Description

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC₅₀ values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC₅₀ > 20 μM). Reduces body temperature in vivo.

Product Specifications for M8 B hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for M8 B hydrochloride

The following data is based on the product molecular weight 432.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.55 mL	23.10 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Almeida Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 2012 PMID: 22323721

Product Documents for M8 B hydrochloride