Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 58N3E1

Format

Azide and BSA Free
View all MAVS Primary Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 93-298 of human MAVS (isoform 1) were used as the immunogen for this antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

Novus Biologicals Mouse MAVS Antibody (58N3E1) - Azide and BSA Free (NBP2-22378) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for MAVS Antibody (58N3E1) - Azide and BSA Free

Western Blot: MAVS Antibody (58N3E1)Azide and BSA Free [NBP2-80840]

Western Blot: MAVS Antibody (58N3E1)Azide and BSA Free [NBP2-80840]

Western Blot: MAVS Antibody (58N3E1) - Azide and BSA Free [NBP2-80840] - Analysis of A) partial recombinant protein and B) human HeLa lysate using IPS-1 antibody at 0.1 ug/ml and 2 ug/ml, respectively. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Image from the standard format of this antibody.
Western Blot: MAVS Antibody (58N3E1)Azide and BSA Free [NBP2-80840]

Western Blot: MAVS Antibody (58N3E1)Azide and BSA Free [NBP2-80840]

Western Blot: MAVS Antibody (58N3E1) - Azide and BSA Free [NBP2-80840] - Western blot analysis of HEK293 lysate (35 ug per lane, RIPA buffer) using MAVS antibody (NBP2-22378) at 0.3ug/ml. Band observed at ~65kDa. (Expected MW of 56.5kDa according to NP_065797.2). Image from the standard format of this antibody.

Applications for MAVS Antibody (58N3E1) - Azide and BSA Free

Application
Recommended Usage

Western Blot

0.1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

Additional MAVS Products

Product Documents for MAVS Antibody (58N3E1) - Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for MAVS Antibody (58N3E1) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for MAVS Antibody (58N3E1) - Azide and BSA Free

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    • A: MAVS is a 540 aa protein with a predicted size of 56 kDa.
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