MaxiPost

Tocris Bioscience | Catalog # 4949

Potassium channel modulator; exerts subtype-specific effects
Tocris Bioscience

Key Product Details

Description

Potassium channel modulator; exerts subtype-specific effects
View all Voltage-gated Potassium Channel Modulators »

Product Description

MaxiPost is a potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.

Product Specifications for MaxiPost

Molecular Weight

359.70

Formula

C16H10ClF4NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one

CAS Number

187523-35-9

PubChem ID

214350

InChI Key

ULYONBAOIMCNEH-HNNXBMFYSA-N

SMILES

O=C2[C@]([C@]3=CC(Cl)=CC=C3OC)(F)C1=CC=C(C(F)(F)F)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.97 100
Ethanol 35.97 100

Preparing Stock Solutions for MaxiPost

The following data is based on the product molecular weight 359.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.90 mL 27.80 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for MaxiPost

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MaxiPost

For research use only

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  • MaxiPost was used to study BK channel activation on HEK 293 cell line
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 12/04/2018
    MaxiPost(BMS-204352) was used to study BK channel activation on HEK 293 cell line.
    MaxiPost 4949

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