MC 1

Tocris Bioscience | Catalog # 8843

Selective EP300 Degrader (PROTAC®)
Tocris Bioscience
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Key Product Details

Description

Selective EP300 Degrader (PROTAC®)
View all Histone Acetyltransferase Degraders »

Product Description

MC 1 is a selective lysine acetyltransferase EP300 Degrader

PROTAC®. Displays selectivity for EP300 over CREBBP. Comprises an EP300-binding moiety (CPI-1612) joined by a linker to VH032 as the ligand for von Hippel-Lindau E3 ubiquitin ligase. MC 1 inhibits cell proliferation in a subset of cancer cell lines and can be used to investigate the noncatalytic functions of EP300 and CREBBP.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Product Specifications for MC 1

Molecular Weight

1062.35

Formula

C59H71N11O6S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(8-(2-(4-(6-((R)-2-(((S)-2-(4-Cyanophenyl)propyl)amino)-2-phenylacetamido)pyridin-3-yl)-1H-pyrazol-1-yl)acetamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

InChI Key

NKGYKZVOVOJLDL-HITCUEKTSA-N

SMILES

O=C(CCCCCCCNC(CN1N=CC(C2=CC=C(NC([C@H](NC[C@@H](C)C3=CC=C(C#N)C=C3)C4=CC=CC=C4)=O)N=C2)=C1)=O)N[C@H](C(N5[C@H](C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)C[C@@H](O)C5)=O)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.62 10 with gentle warming

Preparing Stock Solutions for MC 1

The following data is based on the product molecular weight 1062.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.41 mL 47.07 mL 94.13 mL
0.5 mM 1.88 mL 9.41 mL 18.83 mL
1 mM 0.94 mL 4.71 mL 9.41 mL
5 mM 0.19 mL 0.94 mL 1.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MC 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MC 1

For research use only

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