MCU i4

Tocris Bioscience | Catalog # 7195

Negative modulator of mitochondrial Ca2+ uniporter (MCU)
Tocris Bioscience

Key Product Details

Description

Negative modulator of mitochondrial Ca2+ uniporter (MCU)
View all Mitochondrial Calcium Uniporter Inhibitors »

Product Description

MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.

Product Specifications for MCU i4

Molecular Weight

377.49

Formula

C23H27N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester

CAS Number

371924-24-2

PubChem ID

1568449

InChI Key

RIWXBJCWHVMATR-UHFFFAOYSA-N

SMILES

CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.87 50
Ethanol 37.75 100

Preparing Stock Solutions for MCU i4

The following data is based on the product molecular weight 377.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.30 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for MCU i4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MCU i4

For research use only

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