MDL 100907

Key Product Details

Product Description

MDL 100907 is a potent and selective 5-HT_2A receptor antagonist (K_i = 0.36 nM, IC₅₀ = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT_2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.

Product Specifications for MDL 100907

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MDL 100907

The following data is based on the product molecular weight 373.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

• Sorensen Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J.Pharmacol.Exp.Ther. 1993 PMID: 8102646
• Ardayfio The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant dr J.Pharmacol.Exp.Ther. 2008 PMID: 18772320
• Kehne Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J.Pharmacol. 1996 PMID: 8627580

Product Documents for MDL 100907