MDL 28170

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury.
   Jantzie L, Getsy P, Firl D, Wilson C, Miller R, Robinson S
   Mol Cell Neurosci, 2014;61(0):152-62.
2. Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets.
   Kraemer B, Campbell R, Schwertz H, Franks Z, Vieira de Abreu A, Grundler K, Kile B, Dhakal B, Rondina M, Kahr W, Mulvey M, Blaylock R, Zimmerman G, Weyrich A
   Blood, 2012;120(25):5014-20.
3. HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension.
   Sun X, Zhou Z, Fink D, Mata M
   Mol Cell Neurosci, 2013;57(0):111-9.
4. Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII.
   Zakharova N, Artemenko E, Podoplelova N, Sveshnikova A, Demina I, Ataullakhanov F, Panteleev M
   PLoS ONE, 2015;10(2):e0116665.
5. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170.
   Chen et al.
   Brain Res., 1997;769:188
6. Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.
   Li et al.
   Neurosci.Lett., 1998;247:17
7. Cell-penetrating inhibitor of calpain.
   Mehdi
   TiBS, 1991;16:150
8. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
   Ai et al.
   J.Neurotrauma, 2007;24:960

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