MDL 28170

Key Product Details

Product Description

Potent, selective inhibitor of calpain and cathepsin B (K_i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Product Specifications for MDL 28170

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MDL 28170

The following data is based on the product molecular weight 382.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.07 mL	26.15 mL
5 mM	0.52 mL	2.61 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

• Ai Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 2007 PMID: 17600513
• Li Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 1998 PMID: 9637399
• Mehdi Cell-penetrating inhibitor of calpain. TiBS 1991 PMID: 1877091
• Chen Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 1997 PMID: 9374290

Product Documents for MDL 28170