MFZ 10-7

Key Product Details

Product Description

MFZ 10-7 is a high affinity negative allosteric modulator at the mGlu₅ receptor (K_i = 0.67 nM). Potently inhibits mGlu₅ glutamate-mediated calcium mobilization (IC₅₀ = 1.22 nM). Inhibits cocaine-taking and cocaine-seeking behavior in rats.

Product Specifications for MFZ 10-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MFZ 10-7

The following data is based on the product molecular weight 272.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.67 mL	18.34 mL	36.67 mL
5 mM	0.73 mL	3.67 mL	7.33 mL
10 mM	0.37 mL	1.83 mL	3.67 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Keck Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. ACS Med.Chem.Lett. 2012 PMID: 22924094
• Keck A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict.Biol. 2014 PMID: 24001208
• Alagille Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg.Med.Chem.Lett. 2011 PMID: 21546249

Product Documents for MFZ 10-7