Milrinone

Key Product Details

Product Description

Milrinone is a potent cAMP phosphodiesterase inhibitor (IC₅₀ = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.

Product Specifications for Milrinone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Milrinone

The following data is based on the product molecular weight 211.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.73 mL	23.67 mL	47.34 mL
5 mM	0.95 mL	4.73 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.73 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Shahid The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 1991 PMID: 1665737
• Tang Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 1994 PMID: 7925608
• Alousi Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 1983 PMID: 6195468

Product Documents for Milrinone