Miro1 Reducer

Key Product Details

Product Description

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC₅₀ = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Product Specifications for Miro1 Reducer

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Miro1 Reducer

The following data is based on the product molecular weight 425.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.48 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Hsieh Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 2019 PMID: 31564441

Product Documents for Miro1 Reducer