MK 0677

Key Product Details

Product Description

MK 0677 is a high affinity ghrelin receptor agonist (pK_i = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC₅₀ = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.

Product Specifications for MK 0677

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK 0677

The following data is based on the product molecular weight 624.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.00 mL	16.01 mL
5 mM	0.32 mL	1.60 mL	3.20 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Patchett Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7624358
• Mucciolo Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a GH secretagogue receptor. Eur.J.Pharmacol. 2004 PMID: 15363972
• Bennett GH secretagogues and GH releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol.Pharmacol. 2009 PMID: 19625579

Product Documents for MK 0677