ML 141

Key Product Details

Product Description

ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC₅₀ = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Product Specifications for ML 141

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 141

The following data is based on the product molecular weight 407.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.27 mL	24.54 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 82 publications citing the usage of this product.

• Hong Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. 2013 PMID: 23382385
• Surviladze A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program 2010 PMID: 21433396

Product Documents for ML 141