ML 162

Key Product Details

Product Description

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀ = 25 and 578 nM for HRAS^G12V-expressing and wild-type BJ fibroblasts, respectively).

Product Specifications for ML 162

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 162

The following data is based on the product molecular weight 477.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.95 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Karaj Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J.Med.Chem. 2022 PMID: 35984756
• Weïwer Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 2012 PMID: 22297109
• Luo Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angew.Chem.Int.Ed.Engl. 2022 PMID: 35924720

Product Documents for ML 162