ML 213

Tocris Bioscience | Catalog # 4519

KV7.2 and KV7.4 channel opener
Tocris Bioscience

Key Product Details

Description

KV7.2 and KV7.4 channel opener
View all Voltage-gated Potassium Channel Activators »

Product Description

ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.

Product Specifications for ML 213

Molecular Weight

257.37

Formula

C17H23NO

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

CAS Number

489402-47-3

PubChem ID

3111211

InChI Key

SIQGKPGBLYKQBB-UHFFFAOYSA-N

SMILES

O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.87 50
Ethanol 12.87 50

Preparing Stock Solutions for ML 213

The following data is based on the product molecular weight 257.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.77 mL 38.85 mL 77.71 mL
2.5 mM 1.55 mL 7.77 mL 15.54 mL
5 mM 0.78 mL 3.89 mL 7.77 mL
25 mM 0.16 mL 0.78 mL 1.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for ML 213

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 213

For research use only

Customer Reviews for ML 213 (1)

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  • ML 213 was used to study Kv11.1 channel activation
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/07/2018
    ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.
    ML 213 4519

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