ML 240

Key Product Details

Product Description

ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC₅₀ = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

Product Specifications for ML 240

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 240

The following data is based on the product molecular weight 396.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.61 mL	63.06 mL	126.12 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
2 mM	1.26 mL	6.31 mL	12.61 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Chou Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 2013 PMID: 23316025

Product Documents for ML 240