ML 297

Tocris Bioscience | Catalog # 5380

Selective Kir3.1/3.2 (GIRK1/2) channel activator
Tocris Bioscience

Key Product Details

Description

Selective Kir3.1/3.2 (GIRK1/2) channel activator
View all Inward Rectifier Potassium Channel Activators »

Product Description

ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.

Licensing Information

Sold under license from Vanderbilt University

Product Specifications for ML 297

Molecular Weight

328.32

Formula

C17H14F2N4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

CAS Number

1443246-62-5

PubChem ID

56642816

InChI Key

IEKSMUSSYJUQMY-UHFFFAOYSA-N

SMILES

O=C(NC2=CC(C)=NN2C3=CC=CC=C3)NC1=CC(F)=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.83 100
Ethanol 16.42 50

Preparing Stock Solutions for ML 297

The following data is based on the product molecular weight 328.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.23 mL 30.46 mL
5 mM 0.61 mL 3.05 mL 6.09 mL
10 mM 0.30 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for ML 297

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 297

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for ML 297 (1)

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  • ML 297 worked ideally and the data obtained with the product was consistent throughout the study
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/31/2018
    ML 297 and ML 277 was used on our University labs to understand potassium channel activation percentage at increasing concentrations. ML 297 worked ideally and the data obtained with the product was consistent throughout the experiment.
    ML 297 5380

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