ML 298 hydrochloride

Key Product Details

Product Description

ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC₅₀ values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.

Product Specifications for ML 298 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 298 hydrochloride

The following data is based on the product molecular weight 468.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.53 mL	42.65 mL	85.31 mL
1.25 mM	1.71 mL	8.53 mL	17.06 mL
2.5 mM	0.85 mL	4.27 mL	8.53 mL
12.5 mM	0.17 mL	0.85 mL	1.71 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• O'Reilly Development of dual PLD1/2 adn PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 2013 PMID: 23445448

Product Documents for ML 298 hydrochloride