ML 299

Key Product Details

Product Description

ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC₅₀ values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.

Product Specifications for ML 299

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 299

The following data is based on the product molecular weight 489.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.22 mL	20.43 mL
5 mM	0.41 mL	2.04 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• O'Reilly Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 2013 PMID: 23445448

Product Documents for ML 299